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AAS and spectrophotometric methods for the determination metoprolol tartrate in tablets

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dc.contributor.authorAlpdogan, G
dc.contributor.authorSungur, S
dc.contributor.institutionauthorALPDOĞAN, Güzin
dc.date.accessioned2026-06-27T12:57:00Z
dc.date.issued1999
dc.description.abstractSensitive and specific atomic adsorption spectroscopy (AAS) and spectrophotometric methods have been developed for the determination of beta adrenergic blocking drug, metoprolol tartrate,The method is based on the formation of Cu(II) dithiocarbamate complex by derivatization of the secondary amino group of metoprolol with CS2 and CuCl2 in the presence of ammonia. The copper-bis(dithiocarbamate) complex was extracted into chloroform and the concentration of metoprolol tartrate was determined directly by spectrophotometric and indirectly by AAS measurement of copper. The two methods developed were applied to the assay of metoprolol tartrate in commercial tablet formulations. The methods were compared statistically with each other and with the high performance liquid chromatography (HPLC) method of USPXXII using t- and F-tests. (C) 1999 Elsevier Science B.V. All rights reserved.en
dc.description.urihttps://doi.org/10.1016/s1386-1425(99)00121-3
dc.identifier.doi10.1016/s1386-1425(99)00121-3
dc.identifier.endpage2709
dc.identifier.issn1386-1425
dc.identifier.issue13
dc.identifier.startpage2705
dc.identifier.urihttps://hdl.handle.net/20.500.14981/48055
dc.identifier.volume55
dc.identifier.wos000083796100014
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofSPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
dc.subjectmetoprolol tatrate
dc.subjectatomic absorption spectrophotometry
dc.subjectUV-VIS spectrophotometry
dc.subjectSpectroscopy
dc.titleAAS and spectrophotometric methods for the determination metoprolol tartrate in tablets
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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