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Synthesis and photophysicochemical studies of poly(ethylene glycol) conjugated symmetrical and asymmetrical zinc phthalocyanines

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dc.contributor.authorDincer, Hatice
dc.contributor.authorMert, Humeyra
dc.contributor.authorCaliskan, Emel
dc.contributor.authorAtmaca, Goknur Yasa
dc.contributor.authorErdogmus, Ali
dc.contributor.institutionauthorYAŞA ATMACA, Göknur
dc.date.accessioned2026-06-27T13:43:35Z
dc.date.issued2015
dc.description.abstractSynthesis and characterization of poly(ethylene glycol) conjugated symmetrical and asymmetrical zinc phthalocyanines (ZnPcs) is described. Copper (I) catalyzed azide-alkyne cycloaddition (CuAAC) click reaction between azide functional methoxypoly(ethylene glycol) (mPEG-N-3) and tetra terminal alkynyl substituted ZnPc yields star polymer with ZnPc core. Furthermore, CuAAC click reaction between asymmetrically terminal alkynyl substituted zinc phthalocyanine (aZnPc) and mPEG-N-3 yields aZnPc end functionalized PEG. Spectral, photophysical (fluorescence quantum yield), photochemical (singlet oxygen (Phi(Delta)), and photodegradation quantum yield (Phi(d)) properties of the symmetrically, and asymmetrically PEGylated ZnPcs are investigated to be used as sensitizers in photodynamic therapy (PDT). The quantum yield values of fluorescence (Phi(F)) and singlet oxygen generation (Phi(Delta)) for water soluble symmetrically PEGylated ZnPc in aqueous solution are calculated as 0.01 and 0.14 respectively, suggesting its potential as photosensitizer in PDT treatment. (C) 2015 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [111T063]
dc.description.sponsorshipScientific Research Projects Department (BAP) of Hitit University [MUH19003.14.003]
dc.description.urihttps://doi.org/10.1016/j.molstruc.2015.08.067
dc.identifier.doi10.1016/j.molstruc.2015.08.067
dc.identifier.eissn1872-8014
dc.identifier.endpage196
dc.identifier.issn0022-2860
dc.identifier.startpage190
dc.identifier.urihttps://hdl.handle.net/20.500.14981/54524
dc.identifier.volume1102
dc.identifier.wos000364268300026
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofJOURNAL OF MOLECULAR STRUCTURE
dc.rightsopenAccess
dc.subjectSymmetrical zinc phthalocyanine
dc.subjectAsymmetrical zinc phthalocyanine
dc.subjectClick
dc.subjectStar polymer
dc.subjectPhotodynamic therapy
dc.subjectHALOGENATED SILICON(IV) PHTHALOCYANINES
dc.subjectWATER-SOLUBLE PHTHALOCYANINES
dc.subjectSTAR POLYMERS
dc.subjectPHOTOSENSITIZER
dc.subjectPORPHYRINS
dc.subjectPEGYLATION
dc.subjectCHLORO
dc.subjectCHAINS
dc.subjectChemistry
dc.titleSynthesis and photophysicochemical studies of poly(ethylene glycol) conjugated symmetrical and asymmetrical zinc phthalocyanines
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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