A novel electro-blown naphthoquinone-anthraquinone-poly(ε-caprolactone) nanofiber: Fabrication and characterization

Abstract

Naphthoquinones and anthraquinones are widely used in biomedical applications owing to their bioactive properties. Consequently, the development of new methods for producing biomaterials containing these compounds is of significant interest. For efficient nanofiber production, the electroblowing method offers several advantages, as it is practical, easy to operate, and relatively low cost. In this study, nanofibers were produced by electroblowing using model naphthoquinone and anthraquinone compounds, including 2-(allylamino)-3-chloronaphthalene-1,4-dione, 1-chloroanthraquinone, and 1,8-dichloroanthraquinone, at concentrations of 1% and 3% by mass relative to poly(epsilon-caprolactone). These nanofibers, produced for the first time using the electroblowing technique, were characterized by FTIR, XRD, TGA, DTG, SEM, and EDS analyses. Their cytotoxicity was evaluated using the MTT assay. The results demonstrate that nanofibers incorporating different naphthoquinone and anthraquinone derivatives can be successfully produced as biomaterials using the electroblowing method.