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Synthesis and characterization of natural lanthanum labelled DOTA-Peptides for simulating radioactive Ac-225 labeling

dc.contributor.authorUcar, Burcu
dc.date.accessioned2026-06-27T14:27:03Z
dc.date.issued2019
dc.description.abstractThis research aimed to assess the labeling procedure of Lanthanum to DOTATATE and PSMA-617 peptide for simulating Actinium-225 (Ac-225) labeling. For this purpose labeling procedure, purification and characterization conditions were optimized. Results showed that for the high reaction yield labeling, microwave heating should be preferred and Sephadex G10 column was found to be more suitable as a purification system compared to Toyopearl column. For the characterization of complex, more precise and reliable results were obtained by the chromatographic system.en
dc.description.urihttps://doi.org/10.1016/j.apradiso.2019.108816
dc.identifier.doi10.1016/j.apradiso.2019.108816
dc.identifier.eissn1872-9800
dc.identifier.issn0969-8043
dc.identifier.pubmed31344650
dc.identifier.urihttps://hdl.handle.net/20.500.14981/60768
dc.identifier.volume153
dc.identifier.wos000520020400016
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofAPPLIED RADIATION AND ISOTOPES
dc.subjectLanthanum (III) chloride
dc.subjectPeptide labeling
dc.subjectAc-225
dc.subjectDOTATATE
dc.subjectPSMA-617
dc.subjectSOMATOSTATIN
dc.subjectCOMPLEXES
dc.subjectChemistry
dc.subjectNuclear Science & Technology
dc.subjectRadiology, Nuclear Medicine & Medical Imaging
dc.titleSynthesis and characterization of natural lanthanum labelled DOTA-Peptides for simulating radioactive Ac-225 labeling
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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