SYNTHESIS AND CHARACTERIZATION OF BIOCONJUGATES OF ANTIGENIC RABIES VIRUS PEPTIDE EPITOPE WITH POLYACRYLIC ACID

Abstract

Rabies virus is a certain acute lethal infection and the causative agent of the Central Nervous System. Rabies, the so-called zoonoses, are among the most important diseases spreading by contagion from animals to humans in several ways. Conjugation of antigenic peptides with adjuvant polymers is valuable for developing new generation peptide vaccine. For this purpose, in this study 31D antigenic peptide epitope of rabies virus was conjugated with polyacrylic acid and this conjugates were characterized with high-performance liquid chromatography and gel permeation chromatography. The results suggest that bioconjugation of peptide and polyacrylic acid has a great potential to be developed into an effective vaccine against to rabies virus. For future studies, in vitro and in vivo studies that will be focused on the development of a new generation peptide vaccine are promising.