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Synthesis of new aryl(hetaryl)-substituted tandospirone analogues with potential anxiolytic activity via reductive Heck type hydroarylations

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dc.contributor.authorGunkara, Omer Tahir
dc.contributor.authorSucu, Bilgesu Onur
dc.contributor.authorOcal, Nuket
dc.contributor.authorKaufmann, Dieter E.
dc.contributor.institutionauthorGÜNKARA, Ömer Tahir
dc.date.accessioned2026-06-27T13:22:19Z
dc.date.issued2013
dc.description.abstractTandospirone (I), developed as an anxiolytic drug, is an aryl-piperazine compound that binds to both 5-HT1A and dopamine D4 receptors. Palladium-catalysed hydroarylation reactions of tandospirone analogues containing an oxygen bridge and 3-(trifluoromethyl)phenyl or 2,3-dichlorophenyl groups were studied in order to find a new stereoselective access to a series of new exo-aryl(hetaryl)-substituted derivatives with potential biological activity.en
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [109T380]
dc.description.sponsorshipYildiz Technical University Scientific Research Projects Coordination Department [2011-01-02-KAP03]
dc.description.urihttps://doi.org/10.2478/s11696-013-0338-4
dc.identifier.doi10.2478/s11696-013-0338-4
dc.identifier.endpage649
dc.identifier.issn0366-6352
dc.identifier.issue6
dc.identifier.startpage643
dc.identifier.urihttps://hdl.handle.net/20.500.14981/52311
dc.identifier.volume67
dc.identifier.wos000316294900008
dc.language.isoeng
dc.publisherVERSITA
dc.relation.ispartofCHEMICAL PAPERS
dc.subjecttandospirone
dc.subjectarylpiperazines
dc.subjectC-C coupling
dc.subjecthydroarylation
dc.subjectheterocycles
dc.subjectSUBSTITUTED TRICYCLIC IMIDES
dc.subjectDOPAMINE D3 RECEPTOR
dc.subjectUNSATURATED DICARBOXIMIDES
dc.subjectPHARMACOLOGICAL AGENTS
dc.subjectEPIBATIDINE
dc.subjectDERIVATIVES
dc.subjectCHEMISTRY
dc.subjectAFFINITY
dc.subjectNUCLEUS
dc.subjectAGONIST
dc.titleSynthesis of new aryl(hetaryl)-substituted tandospirone analogues with potential anxiolytic activity via reductive Heck type hydroarylations
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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