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A novel radiolabeled graft polymer: Investigation of the radiopharmaceutical potential using Albino Wistar rats

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dc.contributor.authorAvcibasi, Ugur
dc.contributor.authorAtes, Buket
dc.contributor.authorUnak, Perihan
dc.contributor.authorGumuser, Fikriye Gul
dc.contributor.authorGulcemal, Suleyman
dc.contributor.authorOl, Kevser Kusat
dc.contributor.authorAkgol, Sinan
dc.contributor.authorTekin, Volkan
dc.date.accessioned2026-06-27T14:19:40Z
dc.date.issued2019
dc.description.abstractFe3O4 magnetic graft-Lys-poly(HEMA) was synthesized, labeled with Tc-99m for the first time and its radiopharmaceutical potential was investigated using animal models in this study. Quality control procedures were carried out using thin layer radiochromatography. The labeling yield of radiolabeled polymer was found to be about 100%. Then, stability and lipophilicity were determined. The lipophilicity of Tc-99m labeled Fe3O4 graft-Lys-poly(HEMA) was found to be 3.77. The serum stability experiments demonstrated that approximately 100% of radiolabeled polymer existed as an intact complex in the rat serum within 240 min. Biodistribution of radiolabeled magnetic graft-Lys-poly(HEMA) was performed on female Albino Wistar rats by scintigraphy and biodistribution studies. High uptake was seen in the stomach, the pancreas, brain, ovarian, intestines and the breast.en
dc.description.sponsorshipManisa Celal Bayar University Coordination Unit of Scientific Research Projects (BAP) [2017-016]
dc.description.urihttps://doi.org/10.1016/j.apradiso.2019.108872
dc.identifier.doi10.1016/j.apradiso.2019.108872
dc.identifier.eissn1872-9800
dc.identifier.issn0969-8043
dc.identifier.pubmed31470192
dc.identifier.urihttps://hdl.handle.net/20.500.14981/59305
dc.identifier.volume154
dc.identifier.wos000498291900045
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofAPPLIED RADIATION AND ISOTOPES
dc.subjectHEMA
dc.subjectL-lysine
dc.subjectGrafted polymer
dc.subjectNanoparticle
dc.subjectTc-99m
dc.subjectIRON-OXIDE NANOPARTICLES
dc.subjectDRUG-DELIVERY-SYSTEM
dc.subjectMAGNETIC NANOPARTICLES
dc.subjectIN-VITRO
dc.subjectTHERAPY
dc.subjectBIODISTRIBUTION
dc.subjectPACLITAXEL
dc.subjectMICROSPHERES
dc.subjectPROGRESS
dc.subjectChemistry
dc.subjectNuclear Science & Technology
dc.subjectRadiology, Nuclear Medicine & Medical Imaging
dc.titleA novel radiolabeled graft polymer: Investigation of the radiopharmaceutical potential using Albino Wistar rats
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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