Synthesis of arylpiperazine substituted bisindolylmethanes as possible pharmacologically active new compounds

Abstract

Nitrogen containing heterocyclic rings with a piperazine group are valuable target compounds in medicinal chemistry due to their diversified biological activities. In recent years, many organocatalytic/metal free synthetic pathways towards bisindolylmethanes have been reported.(1-3) In the present work, we combined bisindolylmethanes with arylpiperazines using hydrophobic moiety (alkyl chain) to obtain heterocycles that can be evaluated in pharmacologically and may be more active than the already active bisindolylmethane alkaloids. [GRAPHICS] .