Yayın:
Synthesis of New Aryl(Hetaryl)-Substituted Tandospirones Under Reductive Heck Type Hydroarylations and Isoxazoline Derivatives via 1,3-Dipolar Cycloaddition Reactions with Expected Anxiolytic Activity

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dc.contributor.authorKulu, Irem
dc.contributor.authorKopruceli, Asli
dc.contributor.authorGoksu, Gokce
dc.contributor.authorOcal, Nuket
dc.date.accessioned2026-06-27T13:19:38Z
dc.date.issued2013
dc.description.abstractThe C-C coupling of bicyclic alkene 4 with aryl and heteroaryl iodides gave under reductive Heck conditions the Caryl(hetaryl), N-[((4-pyrimidin-2-yl) piperazin-1-yl) butyl] substituted bicyclic imides 5a-f. The [3+2] cycloadditions of 4 with various nitrile oxides yielded the bridged isoxazoline derivatives 6-8 with potential biological activity.en
dc.description.sponsorshipScientific and Technological Research Council of Turkey [109T380]
dc.description.urihttps://doi.org/10.2174/1570179411310030010
dc.identifier.doi10.2174/1570179411310030010
dc.identifier.eissn1875-6271
dc.identifier.endpage485
dc.identifier.issn1570-1794
dc.identifier.issue3
dc.identifier.startpage481
dc.identifier.urihttps://hdl.handle.net/20.500.14981/51855
dc.identifier.volume10
dc.identifier.wos000319444200010
dc.language.isoeng
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.relation.ispartofCURRENT ORGANIC SYNTHESIS
dc.subjectAntidepressant drugs
dc.subjectbicyclic imides
dc.subjectbiological activity
dc.subjectC-C coupling
dc.subjectisoxazolines
dc.subjectpalladium(II) acetate
dc.subjectarylpiperazine moiety
dc.subject5-HT1A RECEPTOR LIGANDS
dc.subjectIMIDES
dc.subjectEPIBATIDINE
dc.subjectCHEMISTRY
dc.subjectAFFINITY
dc.titleSynthesis of New Aryl(Hetaryl)-Substituted Tandospirones Under Reductive Heck Type Hydroarylations and Isoxazoline Derivatives via 1,3-Dipolar Cycloaddition Reactions with Expected Anxiolytic Activity
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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