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Production of microneedle patches coated with polyvinyl-alcohol/sucrose/ gentamicin sulfate for skin treatment

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dc.contributor.authorMutlu, Mehmet Eren
dc.contributor.authorAkdag, Zekiye
dc.contributor.authorPilavci, Esra
dc.contributor.authorUlag, Songul
dc.contributor.authorDaglilar, Sibel
dc.contributor.authorGunduz, Oguzhan
dc.date.accessioned2026-06-27T15:00:54Z
dc.date.issued2025
dc.description.abstractIn this study, resin-based microneedle (MN) patches were fabricated using a digital light processing (DLP) printer. The needles were coated with gentamicin sulfate (GEN)-loaded with 13.3 % PVA/25 % sucrose solution by immersion. The SEM results showed that the coating was homogeneous and uniformly conical. Analysing the in vitro release profiles of GEN, it was found that it was ultimately released within 312 h. The compression test results demonstrated that GEN addition increased the compression strength to the value of 2.17 +/- 0.01 N/mm2.en
dc.description.urihttps://doi.org/10.1016/j.matlet.2024.137557
dc.identifier.doi10.1016/j.matlet.2024.137557
dc.identifier.eissn1873-4979
dc.identifier.issn0167-577X
dc.identifier.urihttps://hdl.handle.net/20.500.14981/67149
dc.identifier.volume378
dc.identifier.wos001343854200001
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofMATERIALS LETTERS
dc.subjectDigital light processing (DLP)
dc.subjectBiomaterials
dc.subjectGentamicin sulfate
dc.subjectMicroneedle
dc.subjectPolyvinyl alcohol (PVA)
dc.subjectSucrose
dc.subject3D printing
dc.subjectMaterials Science
dc.subjectPhysics
dc.titleProduction of microneedle patches coated with polyvinyl-alcohol/sucrose/ gentamicin sulfate for skin treatment
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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