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Preliminary Studies on Citotoxicity and Genotoxicity Assessment of the PMMA-TiO2 Nanocompozites for Stereolithographic Complete Dentures Manufacturing

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dc.contributor.authorTotu, Eugenia Eftimie
dc.contributor.authorCristache, Corina Marilena
dc.contributor.authorIsildak, Ibrahim
dc.contributor.authorYildirim, Ridvan
dc.contributor.authorBurlibasa, Mihai
dc.contributor.authorNigde, Mustafa
dc.contributor.authorBurlibasa, Liliana
dc.date.accessioned2026-06-27T14:12:42Z
dc.date.issued2018
dc.description.abstractThe aim of the present study was to characterize and preliminary assess the cytotoxicity and genotoxicity of different PMMA-TiO2 nanocomposites suitable to be used for two-parts stereolithographic complete denture manufacturing. In order to improve mechanical and antibacterial characteristics of the materials for 3D printing dentures, two matrix materials consisting in commercially available solutions of poly(methyl methacrylate) (PMMA), referred as dent-PMMA respectively base-PMMA, have been doped with different amount of TiO2 nanoparticles: 0.4, 0.6, 1.0, and 4.0% by weight. The obtained nanocomposites were structural characterized and assessed for antibacterial activity, cytotoxicity and genotoxicity. The newly obtained nanocomposites presented a good inhibitory action against the considered bacterial species-Staphylococcus aureus, good biocompatibility under 4.0% by weight. The results of the preliminary studies on cytotoxicity and genotoxicity assessment recommends the use of 0.4% TiO2 dent-PMMA and base-PMMA for CAD/CAM additive manufacturing of two-parts complete dentures/overdentures.en
dc.description.sponsorshipRomanian National Authority for Scientific Research and Innovation, CCDI-UEFISCDI within PNCDI III [30/2016]
dc.description.sponsorshipscyentific and technological research council of Turkey, TUBITAK [9150165]
dc.identifier.endpage1165
dc.identifier.issn0034-7752
dc.identifier.issue5
dc.identifier.startpage1160
dc.identifier.urihttps://hdl.handle.net/20.500.14981/58001
dc.identifier.volume69
dc.identifier.wos000434954100026
dc.language.isoeng
dc.publisherCHIMINFORM DATA S A
dc.relation.ispartofREVISTA DE CHIMIE
dc.subjectTiO2-PMMA nanocomposites
dc.subject3D printing
dc.subjectcytotoxicity
dc.subjectgenotoxicity
dc.subjectantibacterial activity
dc.subjectstructural characterization
dc.subjectMANDIBULAR OVERDENTURE.
dc.subjectATTACHMENT SYSTEMS
dc.subjectNANOCOMPOSITES
dc.subjectRESINS
dc.subjectChemistry
dc.subjectEngineering
dc.titlePreliminary Studies on Citotoxicity and Genotoxicity Assessment of the PMMA-TiO2 Nanocompozites for Stereolithographic Complete Dentures Manufacturing
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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