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The Synthesis of Epiboxidine and Related Analogues as Potential Pharmacological Agents

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dc.contributor.authorKulu, Irem
dc.contributor.authorOcal, Nuket
dc.date.accessioned2026-06-27T13:14:04Z
dc.date.issued2011
dc.description.abstractMethyl epiboxidine-N-carboxylate (8) was synthesized from 7 under reductive Heck conditions (Scheme 2). The C?C coupling of the new epiboxidine analog 9 with aryl and heteroaryl halides gave by hydroarylation C-aryl, N-(3-methylisoxazol-5-yl)-substituted tricyclic imides 10a10f (Table). The [3+2] cycloaddition of 9 with nitrile oxides yielded the bridged dihydroisoxazole derivatives 11a11d with potential biological activity (Scheme 4).en
dc.description.sponsorshipScientific and Technological Research Council of Turkey (Tubitak) [109T380]
dc.description.urihttps://doi.org/10.1002/hlca.201100140
dc.identifier.doi10.1002/hlca.201100140
dc.identifier.endpage2060
dc.identifier.issn0018-019X
dc.identifier.issue11
dc.identifier.startpage2054
dc.identifier.urihttps://hdl.handle.net/20.500.14981/50841
dc.identifier.volume94
dc.identifier.wos000297245900013
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofHELVETICA CHIMICA ACTA
dc.subjectHeck reaction
dc.subjectCycloadditions
dc.subjectEpiboxidine
dc.subjectN-(methoxycarbonyl)-
dc.subjectIsoxazolines
dc.subjectDOMINO-HECK REACTIONS
dc.subjectEPIBATIDINE
dc.subjectSYSTEMS
dc.subjectCHEMISTRY
dc.subjectAFFINITY
dc.titleThe Synthesis of Epiboxidine and Related Analogues as Potential Pharmacological Agents
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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