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Development of an Analytical Method for the Determination of Amoxicillin in Commercial Drugs and Wastewater Samples, and Assessing its Stability in Simulated Gastric Digestion

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dc.contributor.authorUnutkan, Tugce
dc.contributor.authorBakirdere, Sezgin
dc.contributor.authorKeyf, Seyfullah
dc.date.accessioned2026-06-27T14:10:41Z
dc.date.issued2018
dc.description.abstractA highly sensitive analytical HPLC-UV method was developed for the determination of amoxicillin in drugs and wastewater samples at a single wavelength (230 nm). In order to substantially predict the in vivo behavior of amoxicillin, drug samples were subjected to simulated gastric conditions. The calibration plot of the method was linear from 0.050 to 500 mg L-1 with a correlation coefficient of 0.9999. The limit of detection and limit of quantitation were found to be 16 and 54 mu g L-1, respectively. The percentage recovery of amoxicillin in wastewater was found to be 97.0 +/- 1.6%. The method was successfully applied for the qualitative and quantitative determination of amoxicillin in drug samples including tablets and suspensions.en
dc.description.sponsorshipYildiz Technical University Research Fund [2014-07-01-KAP01]
dc.description.urihttps://doi.org/10.1093/chromsci/bmx078
dc.identifier.doi10.1093/chromsci/bmx078
dc.identifier.eissn1945-239X
dc.identifier.endpage40
dc.identifier.issn0021-9665
dc.identifier.issue1
dc.identifier.pubmed28977474
dc.identifier.startpage36
dc.identifier.urihttps://hdl.handle.net/20.500.14981/57603
dc.identifier.volume56
dc.identifier.wos000419642600005
dc.language.isoeng
dc.publisherOXFORD UNIV PRESS INC
dc.relation.ispartofJOURNAL OF CHROMATOGRAPHIC SCIENCE
dc.rightsopenAccess
dc.subjectPERFORMANCE LIQUID-CHROMATOGRAPHY
dc.subjectCLAVULANIC ACID
dc.subjectPHARMACEUTICAL FORMULATIONS
dc.subjectBIOLOGICAL-FLUIDS
dc.subjectHPLC METHOD
dc.subjectASSAY
dc.subjectAMOXYCILLIN
dc.subjectPLASMA
dc.subjectANTIBIOTICS
dc.subjectSERUM
dc.subjectBiochemistry & Molecular Biology
dc.subjectChemistry
dc.titleDevelopment of an Analytical Method for the Determination of Amoxicillin in Commercial Drugs and Wastewater Samples, and Assessing its Stability in Simulated Gastric Digestion
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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