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Preparation and optimization of biodegradable self-assembled PCL-PEG-PCL nano-sized micelles for drug delivery systems

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dc.contributor.authorKocabay, Ozlem Gokce
dc.contributor.authorIsmail, Osman
dc.date.accessioned2026-06-27T14:29:14Z
dc.date.issued2021
dc.description.abstractBiodegradable polymeric micelles have potential therapeutic applications; nevertheless, preparing micelles of a specific diameter and uniform size distribution is a challenge. Micelles were formed from the copolymer of poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) and the effect of PCEC molecular weight, PCL/PEG ratio, solvent-water miscibility, solvent concentration on particle size, polydispersity index and zeta potential of micelles were also investigated. The average particle sizes of the PCEC micelles ranged between 225-959 and 232-1211 nm for micelles prepared with acetone and dimethylformamide, respectively. The encapsulation efficiency is 78.98%. These results indicate that PCEC micelles can be used as drug carriers in controlled delivery systems.en
dc.description.sponsorshipResearch Fund of the Yildiz Technical University [2014-07-01-DOP04]
dc.description.urihttps://doi.org/10.1080/00914037.2020.1713784
dc.identifier.doi10.1080/00914037.2020.1713784
dc.identifier.eissn1563-535X
dc.identifier.endpage337
dc.identifier.issn0091-4037
dc.identifier.issue5
dc.identifier.startpage328
dc.identifier.urihttps://hdl.handle.net/20.500.14981/61169
dc.identifier.volume70
dc.identifier.wos000506822300001
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofINTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
dc.subjectPoly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone)
dc.subjectpolymeric micelles
dc.subjectnano-precipitation method
dc.subjectbiodegradable
dc.subjectself-assembly
dc.subjectTRIBLOCK COPOLYMER
dc.subjectGOLD NANOPARTICLES
dc.subjectIN-VITRO
dc.subjectRELEASE
dc.subjectDOXORUBICIN
dc.subjectBIODISTRIBUTION
dc.subjectEFFICIENCY
dc.subjectMaterials Science
dc.subjectPolymer Science
dc.titlePreparation and optimization of biodegradable self-assembled PCL-PEG-PCL nano-sized micelles for drug delivery systems
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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