Ultrasonic synthesis, characterization of -aminoketones by bismuth(III) triflate and determination of antigenotoxic properties

Abstract

Direct-type catalytic Mannich reaction for the synthesis of -aminoketones from cyclohexanone, substituted aromatic amines and aromatic or hetero-aromatic aldehydes has been applied in water with bismuth triflate under ultrasound. Good yields of the expected -aminoketones were obtained from available substrates, at room temperature in 1-2 hours. This study was designed to evaluate the mutagenic and antimutagenic potential of synthesized -aminoketones compounds using Ames/Salmonella and Escherichia coli WP2 bacterial reverse mutation assay systems.