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Reinvestigation of bromination of 8-substituted quinolines and synthesis of novel phthalonitriles

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dc.contributor.authorOkten, Salih
dc.contributor.authorCakmak, Osman
dc.contributor.authorSaddiqa, Aisha
dc.contributor.authorKeskin, Bahadir
dc.contributor.authorOzdemir, Seda
dc.contributor.authorInal, Merve
dc.date.accessioned2026-06-27T13:55:54Z
dc.date.issued2016
dc.description.abstractBromination of a series of 8-substituted quinolines was reinvestigated and specified for optimum yields and isolation conditions. Mono bromination of 8-hydroxyquinoline (2a) and 8-aminoquinoline (2c) gave mixture of mono and dibromo derivatives 5,7-dibromo-8-hydroxyquinoline (3a), 5,7-dibromo-8aminoquinoline (3c), 7-bromo-8-hydroxyquinoline (3d), 5-bromo-8-aminoquinoline (3e) while 8methoxyquinoline (2b) furnished 5-bromo-8-methoxyquinoline (3f) as sole product. Novel phthalonitriles, 4(quinolin-8-yloxy) phthalonitrile (6) and 4-chloro-5-(quinolin-8-yloxy) phthalonitrile (8) of 8-hydroxyquinoline (2a) were synthesized and converted into their respective bromo derivatives 4-(5-bromoquinolin-8yloxy) phthalonitrile (7) and 4-((5-bromoquinolin-8-yl) oxy)-5-chlorophthalonitrile (9).en
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [112T394]
dc.description.sponsorshipKirikkale University Research Fund [2012/122]
dc.description.sponsorshipYildiz Technical University [2015-01-02-GEP01]
dc.description.sponsorshipTurkey Scholarships program - Government of Turkey
dc.identifier.endpage93
dc.identifier.issn1307-6175
dc.identifier.issue4
dc.identifier.startpage82
dc.identifier.urihttps://hdl.handle.net/20.500.14981/55856
dc.identifier.volume9
dc.identifier.wos000411597000002
dc.language.isoeng
dc.publisherACG PUBLICATIONS
dc.relation.ispartofORGANIC COMMUNICATIONS
dc.subjectBromination
dc.subjecthydroxyquinoline
dc.subjectphthalonitrile
dc.subjectmethoxyquinoline
dc.subjectaminoquinoline
dc.subjectCONVENIENT PREPARATION
dc.subjectAROMATIC-COMPOUNDS
dc.subjectDERIVATIVES
dc.subjectEFFICIENT
dc.subjectSYSTEM
dc.subjectINHIBITORS
dc.subjectPHENOLS
dc.subjectChemistry
dc.titleReinvestigation of bromination of 8-substituted quinolines and synthesis of novel phthalonitriles
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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