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Cerebrospinal fluid: A specific biofluid for the biosensing of Alzheimer's diseases biomarkers

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dc.contributor.authorMirzaie, Arezoo
dc.contributor.authorNasrollahpour, Hassan
dc.contributor.authorKhalilzadeh, Balal
dc.contributor.authorJamali, Ali Akbar
dc.contributor.authorSpiteri, Raymond J.
dc.contributor.authorYouse, Hadi
dc.contributor.authorIsildak, Ibrahim
dc.contributor.authorRahbarghazi, Reza
dc.date.accessioned2026-06-27T14:55:59Z
dc.date.issued2023
dc.description.abstractAlzheimer's disease (AD) is the most prevalent neurodegenerative disorder with an irreversible, progressive, and untreatable nature that causes progressive deterioration, loss of neurons, and cognitive and behavioral decline. An exponential growth of AD is expected in the forthcoming decades. Studies show that amyloid b (Ab) and Tau proteins are two key biomarkers of AD. Abnormality in Ab and Tau levels in biofluids - especially cerebrospinal fluid (CSF) - is directly related to AD incidence and progress. Hence, developing sensitive, affordable, and reliable methods for screening and evaluating these biomarker levels is helpful in early diagnosis, tracking, and treatment of AD. This article scrutinizes the possible effect of Alzheimer's condition on CSF. Following a comprehensive summary of biosensors, the latest developed biosensors are discussed for the detection of Ab and Tau in CSF samples. & COPY; 2023 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipNIMAD institute [4002290]
dc.description.urihttps://doi.org/10.1016/j.trac.2023.117174
dc.identifier.doi10.1016/j.trac.2023.117174
dc.identifier.eissn1879-3142
dc.identifier.issn0165-9936
dc.identifier.urihttps://hdl.handle.net/20.500.14981/66386
dc.identifier.volume166
dc.identifier.wos001039716400001
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofTRAC-TRENDS IN ANALYTICAL CHEMISTRY
dc.subjectCerebrospinal fluid
dc.subjectAlzheimer's diseases
dc.subjectBiosensor
dc.subjectAmyloid beta
dc.subjectTau protein
dc.subjectAMYLOID PRECURSOR PROTEIN
dc.subjectTAU-PROTEIN
dc.subjectSENSITIVE DETECTION
dc.subjectELECTROCHEMICAL SENSOR
dc.subjectMAGNETIC NANOPARTICLES
dc.subjectSECONDARY NUCLEATION
dc.subjectHIGH-PERFORMANCE
dc.subjectPRESSURE SENSOR
dc.subjectEARLY-DIAGNOSIS
dc.subjectBETA-PEPTIDE
dc.subjectChemistry
dc.titleCerebrospinal fluid: A specific biofluid for the biosensing of Alzheimer's diseases biomarkers
dc.typeReview
dspace.entity.typePublication
local.import.sourceWOS

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