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Leishmania tropica: The effect of darkness and light on biological activities in vitro

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dc.contributor.authorAllahverdiyev, Adil M.
dc.contributor.authorKoc, Rabia Cakir
dc.contributor.authorAtes, Sezen Canim
dc.contributor.authorBagirova, Malahat
dc.contributor.authorElcicek, Serhat
dc.contributor.authorOztel, Olga Nehir
dc.contributor.institutionauthorÇAKIR, Rabia
dc.date.accessioned2026-06-27T13:14:16Z
dc.date.issued2011
dc.description.abstractLeishmania parasites can be exposed to effects of light in their vectors and hosts, at various periods. However, there is no information about the effects of light on Leishmania parasites. The aim of this study is to investigate the effects of light on various cell parameters of Leishmania tropica, in vitro. All experiments were conducted on L. tropica promastigotes and amastigote-macrophage cultures, using flow cytometric analysis, MU and phenol-sulfuric acid assay. DAPI and Giemsa. The results showed that the morphology of parasites has changed; the cell cycle has been affected and this caused parasites to remain at G0/G1 phase. Furthermore the proliferation, infectivity, glucose consumption and mitochondrial dehydrogenase activities of parasites were decreased. Thus, for the first time, in this study, the effects of light on biological activities of Leishmania parasites were shown. These new information about parasites' biology, would be very important to investigate the effects of light on the parasites in infected vectors and hosts. (C) 2011 Elsevier Inc. All rights reserved.en
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey)
dc.description.urihttps://doi.org/10.1016/j.exppara.2011.04.002
dc.identifier.doi10.1016/j.exppara.2011.04.002
dc.identifier.eissn1090-2449
dc.identifier.endpage323
dc.identifier.issn0014-4894
dc.identifier.issue4
dc.identifier.pubmed21510933
dc.identifier.startpage318
dc.identifier.urihttps://hdl.handle.net/20.500.14981/50883
dc.identifier.volume128
dc.identifier.wos000293670400003
dc.language.isoeng
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.relation.ispartofEXPERIMENTAL PARASITOLOGY
dc.subjectLeishmania
dc.subjectParasitology
dc.subjectLight
dc.subjectCELL-CYCLE REGULATION
dc.subjectCOLORIMETRIC ASSAY
dc.subjectVISIBLE-LIGHT
dc.titleLeishmania tropica: The effect of darkness and light on biological activities in vitro
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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