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Mechanoregulation of clathrin-mediated endocytosis

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dc.contributor.authorFerguson, Joshua P.
dc.contributor.authorHuber, Scott D.
dc.contributor.authorWilly, Nathan M.
dc.contributor.authorAygun, Esra
dc.contributor.authorGoker, Sevde
dc.contributor.authorAtabey, Tugba
dc.contributor.authorKural, Comert
dc.date.accessioned2026-06-27T14:07:29Z
dc.date.issued2017
dc.description.abstractWe characterized the tension response of clathrin-mediated endocytosis by using various cell manipulation methodologies. Elevated tension in a cell hinders clathrin-mediated endocytosis through inhibition of de novo coat initiation, elongation of clathrin coat lifetimes and reduction of high-magnitude growth rates. Actin machinery supplies an inward pulling force necessary for internalization of clathrin coats under high tension. These findings suggest that the physical cues cells receive from their microenvironment are major determinants of clathrin-mediated endocytic activity.en
dc.description.sponsorshipNational Institutes of Health [R01 AI121124]
dc.description.urihttps://doi.org/10.1242/jcs.205930
dc.identifier.doi10.1242/jcs.205930
dc.identifier.eissn1477-9137
dc.identifier.endpage3636
dc.identifier.issn0021-9533
dc.identifier.issue21
dc.identifier.pubmed28923837
dc.identifier.startpage3631
dc.identifier.urihttps://hdl.handle.net/20.500.14981/57298
dc.identifier.volume130
dc.identifier.wos000414149400006
dc.language.isoeng
dc.publisherCOMPANY OF BIOLOGISTS LTD
dc.relation.ispartofJOURNAL OF CELL SCIENCE
dc.rightsopenAccess
dc.subjectClathrin-mediated endocytosis
dc.subjectMembrane tension
dc.subjectMicroaspiration
dc.subjectHypotonic shock
dc.subjectActin dynamics
dc.subjectCELL POLARITY
dc.subjectLEADING-EDGE
dc.subjectDYNAMICS
dc.subjectCYTOSKELETON
dc.subjectINCREASES
dc.subjectSHAPE
dc.subjectDISC
dc.subjectCell Biology
dc.titleMechanoregulation of clathrin-mediated endocytosis
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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