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Drug release kinetics and transport mechanisms of doxorubicin from core-shell delivery systems

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dc.contributor.authorKocabay, Ozlem Gokce
dc.contributor.authorIsmail, Osman
dc.date.accessioned2026-06-27T15:12:36Z
dc.date.issued2025
dc.description.abstractIn the current research drug release kinetics and transport mechanisms of doxorubicin (DOX) from DOX, DOX/valspodar (PSC 833) and DOX/D-alpha- tocopheryl polyethylene glycol 1000 succinate (TPGS 1000) loaded polymeric micelle (PM) delivery systems were studied. Mathematical modeling has shown that the best suitability for release at pH 5.0 medium (R2 > 0.98) is provided by Korsmeyer-Peppas model and drug release kinetics are both anomalous transport (non-Fickian) and Super case II transport. The drug release was considered to fits in both the Korsmeyer-Peppas and Weibull models for DOX release from DOX-PM, DOX/PSC 833-PM, DOX/TPGS 1000-PM at pH 6.5 and pH 7.4 medium.en
dc.description.sponsorshipYildiz Technical University [2014-07-01-DOP04]
dc.description.urihttps://doi.org/10.4025/actascitechnol.v47i1.70363
dc.identifier.doi10.4025/actascitechnol.v47i1.70363
dc.identifier.eissn1807-8664
dc.identifier.issn1806-2563
dc.identifier.issue1
dc.identifier.urihttps://hdl.handle.net/20.500.14981/68972
dc.identifier.volume47
dc.identifier.wos001457303300014
dc.language.isoeng
dc.publisherUNIV ESTADUAL MARINGA, PRO-REITORIA PESQUISA POS-GRADUACAO
dc.relation.ispartofACTA SCIENTIARUM-TECHNOLOGY
dc.rightsopenAccess
dc.subjectdiffusion
dc.subjectdissolution
dc.subjectdrug release mechanism
dc.subjectdrug release modeling
dc.subjecterosion
dc.subjectswelling
dc.subjectTPGS
dc.subjectScience & Technology - Other Topics
dc.titleDrug release kinetics and transport mechanisms of doxorubicin from core-shell delivery systems
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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