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An Alternative Autophagy-Related Mechanism of Chloroquine Drug Resistance in the Malaria Parasite

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dc.contributor.authorKamil, Mohd
dc.contributor.authorAtmaca, Habibe N.
dc.contributor.authorUnal, Sinem
dc.contributor.authorKina, Umit Y.
dc.contributor.authorBurak, Pinar
dc.contributor.authorDeveci, Gozde
dc.contributor.authorYilmaz, Ilknur
dc.contributor.authorAly, Ahmed S., I
dc.date.accessioned2026-06-27T14:41:38Z
dc.date.issued2022
dc.description.abstractWe generated highly chloroquine (CQ)-resistant (ResCQ) Plasmodium yoelii parasites by stepwise exposure to increasing concentrations of CQ and CQ-sensitive parasites (SenCQ) by parallel mock treatments. No mutations in genes that are associated with drug resistance were detected in ResCQ clones. Autophagy-related genes were highly upregulated in SenCQ compared to ResCQ parasites during CQ treatment. This indicates that CQ resistance can be developed in the malaria parasite by the inhibition of autophagy as an alternative drug resistance mechanism.en
dc.description.sponsorshipTubitak 1001 research grant [119Z409]
dc.description.sponsorshipNIH-NIAID grant [1R21AI111058-01A1]
dc.description.urihttps://doi.org/10.1128/aac.00269-22
dc.identifier.doi10.1128/aac.00269-22
dc.identifier.eissn1098-6596
dc.identifier.issn0066-4804
dc.identifier.issue12
dc.identifier.pubmed36342168
dc.identifier.urihttps://hdl.handle.net/20.500.14981/63602
dc.identifier.volume66
dc.identifier.wos000879715100001
dc.language.isoeng
dc.publisherAMER SOC MICROBIOLOGY
dc.relation.ispartofANTIMICROBIAL AGENTS AND CHEMOTHERAPY
dc.rightsopenAccess
dc.subjectmalaria
dc.subjectPlasmodium yoelii
dc.subjectchloroquine
dc.subjectdrug resistance
dc.subjectautophagy
dc.subjectdrug resistance mechanisms
dc.subjectTRANSMEMBRANE PROTEIN PFCRT
dc.subjectPLASMODIUM-FALCIPARUM
dc.subjectMUTATIONS
dc.subjectQUININE
dc.subjectDEATH
dc.subjectMicrobiology
dc.subjectPharmacology & Pharmacy
dc.titleAn Alternative Autophagy-Related Mechanism of Chloroquine Drug Resistance in the Malaria Parasite
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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