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Antibacterial and cellular behavior of PLA-based bacitracin and zataria multiflora nanofibers produced by electrospinning method

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dc.contributor.authorCiftci, Fatih
dc.contributor.authorDuygulu, Nilufer
dc.contributor.authorYilmazer, Yasemin
dc.contributor.authorGunduz, Oguzhan
dc.contributor.authorUstundag, Cem Bulent
dc.date.accessioned2026-06-27T14:38:23Z
dc.date.issued2023
dc.description.abstractIn this study, poly(lactic-acid) (PLA) polymer-based nanofiber (NF) was obtained by the electrospinning method. Antioxidant Zataria Multiflora (ZM, essential oil extract) and antibiotic effective bacitracin (BAC) materials were added to 8% PLA. ZM essential oil was extracted with Rotary and antioxidant components were investigated using GC-MS. While carvacrol constitutes 50% as the main component of ZM, it was seen as 48.06% carvacrol and 25.47% thymol as a content area. It was analyzed that ZM has a total antioxidant rate of 99.87% with 20 components. In antibacterial tests, PLA/BAC/ZM NF showed the best inhibition growth on all microorganisms (Escherichia coli, Staphylococcus aureus, Bacillus cereus, Staphylococcus epidermidis, Bacillus subtilis). In cell XTT cytotoxicity tests, it was observed that the PLA/BAC/ZM NF used in adhesion and 4 ',6-diamidino-2-phenylindole (DAPI) results showed very good adhesion to cells.en
dc.description.sponsorshipYildiz Technical University Scientific Research Projects Coordination Department [FDK-2019-3531]
dc.description.urihttps://doi.org/10.1080/00914037.2021.2008391
dc.identifier.doi10.1080/00914037.2021.2008391
dc.identifier.eissn1563-535X
dc.identifier.endpage334
dc.identifier.issn0091-4037
dc.identifier.issue4
dc.identifier.startpage319
dc.identifier.urihttps://hdl.handle.net/20.500.14981/62975
dc.identifier.volume72
dc.identifier.wos000728152600001
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofINTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
dc.rightsopenAccess
dc.subjectAntioxidant
dc.subjectcarvacrol
dc.subjectdrug
dc.subjectelectrospinning
dc.subjectessential oil
dc.subjectpolymer nanofiber
dc.subjectthymol
dc.subjectIN-VITRO
dc.subjectEXTRACT
dc.subjectGROWTH
dc.subjectBOISS.
dc.subjectMaterials Science
dc.subjectPolymer Science
dc.titleAntibacterial and cellular behavior of PLA-based bacitracin and zataria multiflora nanofibers produced by electrospinning method
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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