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Experimental design of reversed-phase high performance liquid chromatographic conditions for simultaneous determination of ibuprofen, pseudoephedrine hydrochloride, chlorpheniramine maleate, and nipagen

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dc.contributor.authorAsci, B.
dc.contributor.authorDonmez, O. A.
dc.contributor.authorBozdogan, A.
dc.contributor.authorSungur, S.
dc.date.accessioned2026-06-27T12:51:01Z
dc.date.issued2010
dc.description.abstract2(5-1) fractional factorial design was applied to optimize the chromatographic conditions of the RP-HPLC determination of ibuprofen, pseudoephedrine hydrochloride, chlorpheniramine maleate, and nipagen in syrup preparation. All the factors that affect the determination of components and their interactions were investigated. pH, flow rate and solvent ratios for three steps of gradient profile were regarded as factors to be investigated in two levels. The resolution was chosen as analytical response. The limit of quantitations (10 s/m) were found as 0.9, 1.0, 0.4, and 0.12 mu g/mL for ibuprofen, pseudoephedrine hydrochloride, chlorpheniramine maleate, and nipagen, respectively.en
dc.description.urihttps://doi.org/10.1134/s1061934810070142
dc.identifier.doi10.1134/s1061934810070142
dc.identifier.endpage748
dc.identifier.issn1061-9348
dc.identifier.issue7
dc.identifier.startpage743
dc.identifier.urihttps://hdl.handle.net/20.500.14981/47374
dc.identifier.volume65
dc.identifier.wos000279593000014
dc.language.isoeng
dc.publisherMAIK NAUKA/INTERPERIODICA/SPRINGER
dc.relation.ispartofJOURNAL OF ANALYTICAL CHEMISTRY
dc.subjectHUMAN PLASMA
dc.subjectSPECTROPHOTOMETRIC METHODS
dc.subjectPHARMACEUTICAL-PREPARATION
dc.subjectMASS-SPECTROMETRY
dc.subjectOPTIMIZATION
dc.subjectHPLC
dc.subjectINGREDIENTS
dc.subjectSEPARATION
dc.subjectMIXTURES
dc.subjectSAMPLES
dc.subjectChemistry
dc.titleExperimental design of reversed-phase high performance liquid chromatographic conditions for simultaneous determination of ibuprofen, pseudoephedrine hydrochloride, chlorpheniramine maleate, and nipagen
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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