Synthesis of Aloe Vera Loaded Chitosan Nanoparticle with Ionic Gelling Method

Abstract

Aloe Vera, a long-lived and xeromorphic plant, is known for its therapeutic properties. Several beneficial effects have been reported including AV, hypoglycemic, wound and burn healing, gastroprotective, anticancer, antifungal and anti-inflammatory properties. Chitosan, a bio compatible and biodegradable polymer, has attracted the interest of scientists in recent years thanks to its antibacterial, antimicrobial and antifungal effects. In this study, production of AV loaded chitosan nanoparticles was investigated. Tripolyphosphate (TPP) was used as crosslinker. Field Emission Gun Scanning Electron Microscopy (FEG-SEM) was used to determine the surface characterization and size of chitosan nanoparticles produced by ionic gelation technique. In addition, UV-Spectrometry was used to determine the amount of AV loaded into the produced nanoparticles. AV loaded chitosan nanoparticles produced in this study, as well as antibacterial and antifungal properties, as well as the active substance loading capacities are high and can be designed according to the desired area in many areas (cosmetics, pharmaceuticals, biomedical and tissue engineering, etc.) can be used as a candidate material.