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Synthesis and spectral investigation of some methyl-substituted 3-(2-pyridyl)-2-(2-thienyl)thiazolidin-4-one derivatives

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dc.contributor.authorFidan, Ismail
dc.contributor.authorKazaz, Cavit
dc.contributor.authorSahin, Ertan
dc.contributor.authorKaban, Seniz
dc.date.accessioned2026-06-27T12:52:06Z
dc.date.issued2010
dc.description.abstractSome heteroaryl-substituted thiazolidin-4-one derivatives have been synthesised starting from thiophenecarbox-aldehydes, 2-amino-6-methylpyridine and 2-mercaptoacetic acid. However, the use of 2-mercaptopropanoic acid gave the thiazolidinone derivatives as a mixture of cis-and trans-isomers. The configuration of both the cis-and trans-isomers has been established by NOE-difference experiments. Furthermore, the stereochemistry of one of the trans isomers was established by X-ray crystallography.en
dc.description.urihttps://doi.org/10.3184/030823410x12746350585058
dc.identifier.doi10.3184/030823410x12746350585058
dc.identifier.endpage300
dc.identifier.issn1747-5198
dc.identifier.issue5
dc.identifier.startpage296
dc.identifier.urihttps://hdl.handle.net/20.500.14981/47638
dc.identifier.wos000279579500014
dc.language.isoeng
dc.publisherSCIENCE REVIEWS 2000 LTD
dc.relation.ispartofJOURNAL OF CHEMICAL RESEARCH
dc.subjectheteroaryl-substituted thiazolidinone
dc.subjectconfiguration
dc.subjectdiastereomer
dc.subjectNOE-difference
dc.subjectX-ray crystallography
dc.subjectPOTENTIAL ANTITUMOR-ACTIVITY
dc.subject4-THIAZOLIDONE DERIVATIVES
dc.subjectANTICONVULSANT PROPERTIES
dc.subjectAGENTS
dc.subjectChemistry
dc.titleSynthesis and spectral investigation of some methyl-substituted 3-(2-pyridyl)-2-(2-thienyl)thiazolidin-4-one derivatives
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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