Yayın:
Amoxicillin Loaded Hollow Microparticles in the Treatment of Osteomyelitis Disease Using Single-Nozzle Electrospinning

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dc.contributor.authorAltun, Esra
dc.contributor.authorAydogdu, Mehmet Onur
dc.contributor.authorKoc, Fatma
dc.contributor.authorKutlu, Ozlem
dc.contributor.authorGozuacik, Devrim
dc.contributor.authorYucel, Sevil
dc.contributor.authorGunduz, Oguzhan
dc.date.accessioned2026-06-27T14:15:36Z
dc.date.issued2018
dc.description.abstractIn this study, hollow microparticles were produced with polymethylsilsesquioxane/chitosan/bovine hydroxyapatite/hexagonal boron nitride (PCBB) polyblend using single-nozzle electrospinning method. Also, hollow microparticles are loaded with amoxicillin (AMX) and their drug delivery capabilities have been studied according to a treatment of osteomyelitis disease. The morphology, chemical groups, particle size, antimicrobial activity, and AMX drug release were systematically studied using scanning electron microscopy (SEM), optical microscopy, Fourier transformation infrared spectroscopy (FTIR), hollow microparticle size measurements, antimicrobial activity test, and UV spectroscopy. In vitro biocompatibility was analyzed with human bone osteosarcoma (U2OS) cell line. This present work can help in the design of a drug delivery platform for antimicrobial effect and bone repair at the same time for osteomyelitis disease treatment.en
dc.description.urihttps://doi.org/10.1007/s12668-018-0539-y
dc.identifier.doi10.1007/s12668-018-0539-y
dc.identifier.eissn2191-1649
dc.identifier.endpage801
dc.identifier.issn2191-1630
dc.identifier.issue3
dc.identifier.startpage790
dc.identifier.urihttps://hdl.handle.net/20.500.14981/58561
dc.identifier.volume8
dc.identifier.wos000444750500009
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofBIONANOSCIENCE
dc.subjectSingle-nozzle electrospinning
dc.subjectHollow microparticles
dc.subjectOsteomyelitis
dc.subjectDrug delivery
dc.subjectBone tissue engineering
dc.subjectSILICA NANOPARTICLES
dc.subjectMESOPOROUS SILICA
dc.subjectBONE
dc.subjectINFECTION
dc.subjectMICROSPHERES
dc.subjectPENETRATION
dc.subjectFABRICATION
dc.subjectNANOFIBERS
dc.subjectSTABILITY
dc.subjectPARTICLES
dc.subjectMaterials Science
dc.titleAmoxicillin Loaded Hollow Microparticles in the Treatment of Osteomyelitis Disease Using Single-Nozzle Electrospinning
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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