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Synthesis of New 5-Oxazolones: Their Ring Opening Reactions to Obtain New Benzamide Derivatives

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dc.contributor.authorGunkara, Omer Tahir
dc.contributor.authorGuleli, Muge
dc.contributor.authorCevikkalp, Senem Akkus
dc.contributor.authorKaya, Kerem
dc.contributor.authorOcal, Nuket
dc.date.accessioned2026-06-27T13:59:21Z
dc.date.issued2017
dc.description.abstractNew 5-oxazolones have been synthesized via N-protected amino acids which were prepared from various aryl acyl halides and L-amino acids, with DCC. Then, we studied the ring opening reactions of 5-oxazolones with nucleophilic attack by primary aryl amines to obtain new racemic benzamide derivatives. All new synthesized compounds have been characterized by FTIR, H-1, C-13 NMR, GC/MS, LC/MS and Qtof analyses. X-Ray results of N-(1-((4-chlorophenyl) amino)-3-methyl-1-oxopentan-2-yl)-3-(trifluoromethyl) benzamide clearly showed absolute stereostructure.en
dc.description.sponsorshipYildiz Technical University Scientific Research Projects Coordination Department [2013-01-02 KAP 05]
dc.description.urihttps://doi.org/10.2174/1570179413666161031164124
dc.identifier.doi10.2174/1570179413666161031164124
dc.identifier.eissn1875-6271
dc.identifier.endpage290
dc.identifier.issn1570-1794
dc.identifier.issue2
dc.identifier.startpage283
dc.identifier.urihttps://hdl.handle.net/20.500.14981/56302
dc.identifier.volume14
dc.identifier.wos000394381000014
dc.language.isoeng
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.relation.ispartofCURRENT ORGANIC SYNTHESIS
dc.subjectBenzamides
dc.subjectbiological activity
dc.subjectheterocycles
dc.subjectnucleophilic attack
dc.subject5-oxazolone
dc.subjectring opening reactions
dc.subjectACID
dc.subjectINHIBITORS
dc.subjectRESOLUTION
dc.subjectMECHANISM
dc.subjectChemistry
dc.titleSynthesis of New 5-Oxazolones: Their Ring Opening Reactions to Obtain New Benzamide Derivatives
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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