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Ibuprofen release from porous hydroxyapatite tablets

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dc.contributor.authorOner, Mualla
dc.contributor.authorYetiz, Erman
dc.contributor.authorAy, Esin
dc.contributor.authorUysal, Umut
dc.contributor.institutionauthorÖNER, Mualla
dc.date.accessioned2026-06-27T13:13:45Z
dc.date.issued2011
dc.description.abstractThe present study investigated drug release profiles from porous hydroxyapatite [Ca-5(PO4)(3)OH, HAP] tablets. HAP tablets prepared synthetically and porous structure was generated via microemulsion after sintering at 700 degrees C. The influence of tablet's microemulsion concentration on drug release profiles from sintered porous tablets was investigated by using ibuprofen (C13H18O2) as model drug. A numerical approach based on Fick's second diffusion law was used to investigate drug release kinetics from porous HAP tablets. Via this equation, diffusion coefficients were calculated for each tablet and compared. Drug release from the tablets was influenced by the porosity and tortuosity of the porous network. The drug release from porous HAP tablets was increased by microemulsion concentration. It is possible to obtain HAP based drug delivery system which has different drug release behavior by controlling microemulsion concentration in tablets before sintering. (C) 2011 Elsevier Ltd and Techna Group S.r.l. All rights reserved.en
dc.description.sponsorshipYTUAF [27-07-01-02]
dc.description.sponsorshipDPT [24-DPT-07-04-01, 25-DPT-07-04-01]
dc.description.urihttps://doi.org/10.1016/j.ceramint.2011.02.021
dc.identifier.doi10.1016/j.ceramint.2011.02.021
dc.identifier.eissn1873-3956
dc.identifier.endpage2125
dc.identifier.issn0272-8842
dc.identifier.issue7
dc.identifier.startpage2117
dc.identifier.urihttps://hdl.handle.net/20.500.14981/50773
dc.identifier.volume37
dc.identifier.wos000293759300009
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofCERAMICS INTERNATIONAL
dc.subjectBiomedical applications
dc.subjectHydroxyapatite
dc.subjectDrug release
dc.subjectIbuprofen
dc.subjectCALCIUM-PHOSPHATE CEMENT
dc.subjectDRUG-DELIVERY SYSTEM
dc.subjectMIXING SOLUTION VOLUME
dc.subjectIN-VITRO
dc.subjectINDOMETHACIN RELEASE
dc.subjectTEMPERATURE
dc.subjectFABRICATION
dc.subjectMCM-41
dc.subjectMaterials Science
dc.titleIbuprofen release from porous hydroxyapatite tablets
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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