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Hydroarylation of bicyclic, unsaturated dicarboximides: access to aryl-substituted, bridged perhydroisoindoles

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2008

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item.page.editor

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PERGAMON-ELSEVIER SCIENCE LTD

DOI

10.1016/j.tetlet.2008.02.171

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Article
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Abstract

The C-C coupling of the two bicyclic, unsaturated dicarboximides 6 and 8 with aryl and hetaryl halides gave under reductive Heck conditions the 5-substituted N-phenylbicyclo[2.2.1]heptane-2,3-dicarboxim ides 7 and 9. Reduction of these imides opens a new access to the bridged perhydroisoindole derivatives 12 and 14 with prospective biological activity. (c) 2008 Elsevier Ltd. All rights reserved.

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TETRAHEDRON LETTERS

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0040-4039

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Keywords

palladium , homogenous catalysis , C-C coupling , reduction , amine , aromatics , PALLADIUM-CATALYZED REACTIONS , DOMINO-HECK REACTIONS , CYCLIC IMIDES , EPIBATIDINE , AMINES , Chemistry

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https://hdl.handle.net/20.500.14981/50352

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