Yayın: Hydroarylation of bicyclic, unsaturated dicarboximides: access to aryl-substituted, bridged perhydroisoindoles
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PERGAMON-ELSEVIER SCIENCE LTD
DOI
10.1016/j.tetlet.2008.02.171
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Özet
The C-C coupling of the two bicyclic, unsaturated dicarboximides 6 and 8 with aryl and hetaryl halides gave under reductive Heck conditions the 5-substituted N-phenylbicyclo[2.2.1]heptane-2,3-dicarboxim ides 7 and 9. Reduction of these imides opens a new access to the bridged perhydroisoindole derivatives 12 and 14 with prospective biological activity. (c) 2008 Elsevier Ltd. All rights reserved.
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TETRAHEDRON LETTERS
ISSN
0040-4039