Yayın: Evaluation of mono- and dipeptides as organocatalysts for enantioselective aldol reaction
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Yayıncı
PERGAMON-ELSEVIER SCIENCE LTD
DOI
10.1016/j.tet.2014.04.016
Türü
Özet
Catalytic activities of (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (THIQA)-based mono- and dipeptides and their L-proline analogs in asymmetric aldol reaction were investigated. THIQA-based dipeptides showed better enantioselectivity than proline analogs, whereas proline-based dipeptides gave higher yield in the aldol reaction of cyclohexanone with several aldehydes in dichloromethane at -10 degrees C in the presence of benzoic acid. (C) 2014 Elsevier Ltd. All rights reserved.
Tanım
Dergi veya Seri
TETRAHEDRON
ISSN
0040-4020