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Evaluation of mono- and dipeptides as organocatalysts for enantioselective aldol reaction

dc.contributor.authorYolacan, Cigdem
dc.contributor.authorMavis, Murat Emrah
dc.contributor.authorAydogan, Feray
dc.date.accessioned2026-06-27T13:27:54Z
dc.date.issued2014
dc.description.abstractCatalytic activities of (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (THIQA)-based mono- and dipeptides and their L-proline analogs in asymmetric aldol reaction were investigated. THIQA-based dipeptides showed better enantioselectivity than proline analogs, whereas proline-based dipeptides gave higher yield in the aldol reaction of cyclohexanone with several aldehydes in dichloromethane at -10 degrees C in the presence of benzoic acid. (C) 2014 Elsevier Ltd. All rights reserved.en
dc.description.sponsorshipYildiz Technical University Scientific Research Foundation [2011-01-02-KAP-02]
dc.description.urihttps://doi.org/10.1016/j.tet.2014.04.016
dc.identifier.doi10.1016/j.tet.2014.04.016
dc.identifier.endpage3713
dc.identifier.issn0040-4020
dc.identifier.issue23
dc.identifier.startpage3707
dc.identifier.urihttps://hdl.handle.net/20.500.14981/52879
dc.identifier.volume70
dc.identifier.wos000336191600009
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofTETRAHEDRON
dc.subjectAldol reaction
dc.subjectTetrahydroisoquinoline-3-carboxylic acid
dc.subjectProline
dc.subjectOrganocatalysis
dc.subjectAsymmetric synthesis
dc.subjectSMALL ORGANIC-MOLECULES
dc.subjectTHIOUREA BIFUNCTIONAL CATALYSTS
dc.subjectPROLINE-BASED ORGANOCATALYST
dc.subjectASYMMETRIC MICHAEL ADDITION
dc.subjectAMIDE
dc.subjectALDEHYDES
dc.subjectWATER
dc.subjectDERIVATIVES
dc.subjectINHIBITORS
dc.subjectChemistry
dc.titleEvaluation of mono- and dipeptides as organocatalysts for enantioselective aldol reaction
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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