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Radiation induced formation of poly (N-isopropyl acrylamide)-bovine serum albumin covalent conjugates and their immunogenicity

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dc.contributor.authorVural, P.
dc.contributor.authorKarahan, M.
dc.contributor.authorArayici, P. Pelit
dc.contributor.authorMustafaeva, Z.
dc.date.accessioned2026-06-27T14:06:45Z
dc.date.issued2017
dc.description.abstractPoly (N-isopropyl acrylamide) was bioconjugated to bovine serum albumin by Co-60 gamma-rays at pH 7. The covalent binding mechanism of the radiation induced poly (N-isopropyl acrylamide)-bovine serum albumin conjugate Was analyzed by high performance liquid chromatography while the immunization property was analyzed by ELISA tests. High performance liquid chromatography results showed the conjugate formation of polymer with protein and also the increase in the radio stability of the protein as a result of this formation. The immunization results of irradiated conjugates in Balb/c mice were significantly higher than the free BSA immunization results. This, system is attractive for application of a novel immunogenic model system in vaccine technology.en
dc.identifier.endpage561
dc.identifier.issn0324-1130
dc.identifier.issue3
dc.identifier.startpage557
dc.identifier.urihttps://hdl.handle.net/20.500.14981/57153
dc.identifier.volume49
dc.identifier.wos000412254400001
dc.language.isoeng
dc.publisherBULGARIAN ACAD SCIENCE
dc.relation.ispartofBULGARIAN CHEMICAL COMMUNICATIONS
dc.subjectImmunization
dc.subjectIrradiation
dc.subjectPolyelectrolytes
dc.subjectProteins
dc.subjectVaccine
dc.subjectBIODEGRADABLE NANOPARTICLES
dc.subjectDELIVERY
dc.subjectDRUG
dc.subjectChemistry
dc.titleRadiation induced formation of poly (N-isopropyl acrylamide)-bovine serum albumin covalent conjugates and their immunogenicity
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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