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Rheological behavior and injectability of PEG/glycerol/bioactive glass-based bone grafts incorporating Denosumab

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dc.contributor.authorOzel, Cem
dc.contributor.authorOzarslan, Ali Can
dc.contributor.authorYucel, Sevil
dc.date.accessioned2026-06-27T15:25:01Z
dc.date.issued2025
dc.description.abstractIn this study, injectable bone graft putty samples were developed using fine and coarse melt-quenched 45S5 bioactive glass (BG) incorporated into a carrier system composed of glycerol and polyethylene glycol (PEG) with different average molecular weights. Selected putty samples were further incorporated with varying amounts of Denosumab (5wt%-10wt%) to investigate its influence on rheological behavior and flow properties using mathematical modeling. All PEG/glycerol/45S5-based putty samples exhibited viscoelastic behavior (storage modulus > loss modulus) and pseudoplastic behavior (n 0.95). This study highlights the influence of Denosumab on flowability and rheological relationships and suggests potential improvements in bioactivity through a dual synergistic effect of BG and Denosumab in minimally invasive bone graft systems.en
dc.description.sponsorshipYildiz Technical University Scientific Research Projects Coordination Unit [FBA-2023-5377]
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [BIDEB/2211-A, 2250]
dc.description.urihttps://doi.org/10.1007/s12613-025-3263-y
dc.identifier.doi10.1007/s12613-025-3263-y
dc.identifier.eissn1869-103X
dc.identifier.endpage3104
dc.identifier.issn1674-4799
dc.identifier.issue12
dc.identifier.startpage3086
dc.identifier.urihttps://hdl.handle.net/20.500.14981/70717
dc.identifier.volume32
dc.identifier.wos001621399900015
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofINTERNATIONAL JOURNAL OF MINERALS METALLURGY AND MATERIALS
dc.subjectbioactive glass
dc.subjectbiomaterial
dc.subjectDenosumab
dc.subjectinjectable bone graft
dc.subjectinjectability
dc.subjectputty
dc.subjectsynergetic effect
dc.subjectrheology
dc.subjectPARTICLE-SIZE DISTRIBUTION
dc.subjectVISCOELASTIC PROPERTIES
dc.subjectMECHANICAL-PROPERTIES
dc.subjectSCAFFOLDS
dc.subjectGLYCEROL
dc.subjectBIOCOMPOSITES
dc.subjectNANOSPHERES
dc.subjectPROPERTY
dc.subjectLIQUID
dc.subjectCEMENT
dc.subjectMaterials Science
dc.subjectMetallurgy & Metallurgical Engineering
dc.subjectMining & Mineral Processing
dc.titleRheological behavior and injectability of PEG/glycerol/bioactive glass-based bone grafts incorporating Denosumab
dc.typeArticle
dspace.entity.typePublication
local.import.sourceWOS

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