Özet:
Mass spectrometry has played a key role in inorganic chemical metrology for more
than 25 years. Applications of inductively coupled plasma mass spectrometry (ICPMS) allow wide variety of challenging measurements using different calibration
strategies and methodologies with developing technologies. This thesis
demonstrates some of the advance applications of ICP-MS in different research
areas.
In the first chapter, ICP-MS/MS was used in the certification measurements of a
candidate seawater reference material. Chemistry Laboratories of TÜBİTAK
National Metrology Institute (UME) leaded to process and perform the
certification measurements for UME CRM 1206. To be used in certification
measurements, isotope dilution mass spectrometry (IDMS) which is a potentially
primary technique and triethylamine assisted Mg(OH)2 co-precipitation strategy
(TEA/Mg(OH)2) were combined and validated for target analytes.
In the second chapter, the investigation of plant metabolization performing total
elemental and speciation analyses were conducted by ICP-MS/MS. Vegetables
from the Allium genus are of particular importance due to being potential sources
of selenium. In this thesis, the metabolization of inorganic selenium fortification
of Allium porrum (Leek) at different levels in hydroponic medium was
investigated. Growth effect of selenium fortification, uptake and
biotransformation rate of inorganic selenium species, translocations,
bioavailability and bioaccessibility of selenium were investigated.
In the last chapter, pre-investigation for provenance of walnuts were performed
by multi element profiling on the walnuts samples and their provenance soils. In
the multi element profiling study, walnut samples were analyzed using a high
resolution ICP-MS (HR-ICP-MS), while soil analyses were done by using HR-ICPMS and ICP-OES. Optimization of digestion procedures for walnuts and soils were
performed and precision, trueness and measurement uncertainties of the proposed
methods were evaluated during the method developments. The relationship of
elements in walnut and also between walnuts and their soils of origin were
evaluated according to the one-to-one correlation coefficient of the elements and
the correlation coefficient of different elements pairs.
